Patients with metastatic CC harbouring certain BRAF mutations may respond to anti-EGFR

Patients with metastatic colorectal cancer harbouring a subset of non-V600 mutations in the BRAF gene, known as class 3 BRAF mutations, are more likely to respond to anti-EGFR treatment, according to a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

Early onset colorectal cancer rising in many high-income countries

A new American Cancer Society study has reported that colorectal cancer (CRC) incidence is increasing exclusively in young adults in nine high-income countries spanning three continents. The study, ‘Global patterns and trends in colorectal cancer incidence in young adults’, appearing in the journal Gut, finds the rising rates are in contrast to stable or declining trends in older adults, suggesting that changes in early-life exposures are increasing CRC risk.

More colorectal cancer testing choices does not increase screening rates

Offering patients the choice between home screening or in-office colonoscopy does not increase participation in colorectal cancer screening, according to a new Penn Medicine study. However, the framing of choice did impact patient decision-making, as the proportion of colonoscopies - the gold standard for colorectal cancer screening - fell when the home screening option was presented as an available option. This study was published in JAMA Network Open.

Frying oil consumption worsens colon cancer and colitis in mice

Researchers at UMass Amherst - examining the impact of frying oil consumption on inflammatory bowel disease (IBD) and colon cancer in animal models – have reported that dietary administration of frying oil exaggerated development of IBD and IBD-associated colon tumorigenesis in mice, and these effects could be mediated by the polar compounds in the frying oil.

Disposable colonoscopy devices may not be cost-effective in high-volume centres

A team of Johns Hopkins data researchers studying the economic and safety implications associated with disposable colonoscopy devices has that while disposable devices might lead to lower rates of post-colonoscopy infection, institutions that perform the procedure thousands of times per year might better benefit from improved disinfection methods of reusable scopes. The study, ‘The hidden cost of colonoscopy including cost of reprocessing and infection rate: the implications for disposable colonoscopes’, was published in the journal Gut.

Phone texts increase rates of colonoscopies

Having simple text conversations with patients one week before they are scheduled for a colonoscopy dramatically decreased the ‘no-show’ rates, according to a study conducted by Penn Medicine researchers. Through sending reminders and instruction, opening the door for patients to ask questions, and sharing helpful links, the team increased rate of colonoscopies to 90 percent - well above the 62 percent success rate seen in a group who did not receive this extra communication.

Scottish waiting times to diagnose bowel cancer show improvement, but more must be done

Since the publication of Scotland’s National Endoscopy Action Plan in March 2019 fewer Scottish patients are waiting longer than six weeks for key tests that can diagnose bowel cancer. However, two thirds of Scottish health Boards continue to breach the national standard that patients should be waiting no more than six weeks for a lower GI endoscopy or colonoscopy.