Time to read
2 minutes
Read so far

Researchers propose widespread banking of stool samples for autologous faecal microbiota transplant later in life

Tue, 07/05/2022 - 12:16
Posted in:

Researchers from Harvard Medical School and Brigham and Women's Hospital (BWH) have proposed that having individuals bank samples of people’s own gut microbiota when they are young and healthy for potential use later in life in an autologous faecal microbiota transplant (FMT). The findings were reported in the paper, ‘Rejuvenating the human gut microbiome', published in Trends in Molecular Medicine.

"The idea of 'rewilding' the human microbiome has taken off in recent years and has been hotly debated from medical, ethical, and evolutionary perspectives," explained corresponding author, Dr Yang-Yu Liu, an Associate Professor of Medicine at Harvard and an Associate Scientist in the Channing Division of Network Medicine at BWH. "It is still unknown if people in industrialised societies can gain some health benefit by restoring their microbiome to an ancestral state. In this paper, we proposed a way to rejuvenate the human gut microbiome."

FMTs using donor stool have shown benefit for treating some conditions, primarily infections with Clostridioides difficile (C. diff), which affect about half a million people and kill about 29,000 in the US every year. However, one limitation of using donor stool is variability in the host's response, likely due to genetic and environmental differences between the donor and host.

Efforts in Yang's lab focus on understanding the ecological dynamics and organizational principles of the human microbiome to inform the design of microbiome-based therapeutics. OpenBiome, a nonprofit stool bank based in Somerville, MA, is the first stool bank to offer an option for individuals to bank their own stool for future treatment of C. diff infection. Yang and his colleagues looked at whether this approach might be feasible on a large scale for many other diseases.

"Conceptually, the idea of stool banking for autologous FMT is similar to when parents bank their baby's cord blood for possible future use," added Yang. "However, there is greater potential for stool banking, and we anticipate that the chance of using stool samples is much higher than for cord blood. But there are many practical issues to implementing this idea.

The article takes a closer look at some of those issues, including optimal storage methods, how much stool should be banked and what the costs might be.

"Autologous transplants would naturally avoid or at least mitigate donor-recipient compatibility issues, but a major disadvantage of autologous transplants is the need for long-term cryopreservation of stool samples, typically requiring liquid nitrogen storage," said co-author, Dr Shanlin Ke, a postdoctoral research fellow in Yang's lab. "The long-term safe storage and subsequent resuscitation and cultivation of stool samples is a fundamental research question by itself. To inform practical guidelines for stool banking, further research is needed to systematically test longer storage times and preservation, resuscitation, and cultivation procedures."

Yang acknowledges that widespread banking could lead to a system in which those with more financial resources are more likely to have banked stool for future use.

"We do not anticipate that all individuals in our society are willing or able to pay the cost associated with the service of 'rejuvenating' their gut microbiome, in the same way that not all parents pay the cost of cord blood banking for their newborns," he said. "But as scientists our job is to provide a scientific solution that may eventually benefit human well-being. Developing a reasonable business model and pricing strategy so that the solution is affordable to everyone would require the joint force of entrepreneurs, scientists, and perhaps governments."

"Autologous FMTs have the potential to treat autoimmune diseases like asthma, multiple sclerosis, inflammatory bowel disease, diabetes, obesity, and even heart disease and aging," added co-author, Dr Scott T Weiss, a Professor of Medicine at Harvard and Associate Director of the Channing Division of Network Medicine at BWH. "We hope this paper will prompt some long-term trials of autologous FMTs to prevent disease."

To access this paper, please click here